Endocrine Abstracts

Introduction: Retrospective study of patients undergoing thyroid surgery at the Hospital Virgen de la Luz, Cuenca (Spain) during the years 2010–2013.Material and methods: We evaluated data of 92 patients basically with nodular thyroid disease, who were studied and treated in our hospital.Results: Our series is made up of 92 patients (25% men and 75% women) with an average age of 52 years. The most common form of presentation (...

Introduction, material and methods: Differentiated thyroid cancer is a pretty common reason for consulting in our specialty. In general terms, the prognosis is good in the main histological type but there are many others that can worsen the prognosis. It can determine the kind of surgery from hemithyroidectomy (e.g. microcarcinoma) to no intervention because of its extension at the moment of diagnosis. We have collected the data of our patients with differentiated thyroid canc...

Introduction: Everolimus is a drug selective inhibitor of mTOR and approved by the FDA in 2011 for treatment of neuroendocrine tumors of pancreatic origin unresectable. Our objective was to evaluate the efficacy and safety of everolimus in a patient with malignant pancreatic head insulinoma.Case: This is a 31 year old man who complains of epigastric pain, dizziness, sweating and syncope related to exercise. During admission is objectively severe hypoglyc...

Introduction and objectives: In clinical practice many professionals are involved in the diabetes treatment. To facilitate this work, we present a computer program, based in recommended guidelines, to improve the management of insulin therapy, called insulinator. We evaluated the correlation between these and clinical practice.Materials and methods: Insulinator has been made so that using a number of variables (weight, HbA1c and glycemic control) offer a...

Introduction and objectives: Multiple surgeries are associated with many complications in the local recurrence of papillary thyroid carcinoma. Our objective is to evaluate the efficiency of the enolization in the recurrent metastatic cervical lymph nodes in patients with limited nodal disease.Material and methods: We studied 13 patients (six males and seven females) with a mean age of 43±14.4 years with papillary thyroid carcinoma intervened (total ...

Introduction, material and methods: The BRAF isoform of RAF has been implicated in the pathogenesis of papillary thyroid cancer, but not of benign or follicular neoplasms. Also, BRAF mutations may confer a worse clinical prognosis than for papillary thyroid cancer without the BRAF mutation. Recurrence occurs more frequently when BRAF mutations are present. In addition, BRAF mutations are associated with extrathyroidal invasion, lymph node me...

Introduction: The gold standard for evaluating Occult Parathyroid Adenomas (OPa) in patients with biochemical pattern of primary hyperparathyroidism (PHPT) is the 99mTc-MIBI parathyroid scan. 18F-Fluorocholine (18F-FCH) PET/CT has been proposed as a potential technique for detection and localization of OPa when 99mTc-MIBI scan is negative or inconclusive.Aims: To evaluate sensitivity and positive predictive value of 18F-Fluorocholine PET/CT in patients w...

Introduction: Hereditary phaeochromocytoma (PCC) and paraganglioma (PGL) account for 30–35% of cases and have some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients (n=36, 27 with PCC and 9 with PGL) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984 and 2013; 33% were germline mutation carriers (25% pseudohypoxic [PH] phenotype, 75% MAP-kinas...

Introduction: Hereditary Medullary Thyroid Cancer (MTC) accounts for 20–30% of cases and has some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients with MTC (n=48) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984–2013; 42% were germline mutation carriers (45% moderate risk (category MOD), 45% high risk (category H), 10% highest risk (ca...

Introduction and objectives: The localization of primary hyperaldosteronism is often difficult. The coexistence of nonfunctioning adenomas is common in patients older 40 years old and small adenomas undetectable by CT could confuse with bilateral hyperplasia. The AVS is considered the ‘gold standard’ test for the location of numerous guides. We describe our experience in a clinical case of primary aldosteronism.Clinical case: We present a 58 ye...